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Fernando Larrea Selected Research

Astemizole

1/2019ASTEMIZOLE, AN INHIBITOR OF ETHER-À-GO-GO-1 POTASSIUM CHANNEL, INCREASES THE ACTIVITY OF THE TYROSINE KINASE INHIBITOR GEFITINIB IN BREAST CANCER CELLS.
10/2014In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors.
1/2012Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy.

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Fernando Larrea Research Topics

Disease

22Neoplasms (Cancer)
10/2022 - 10/2004
14Breast Neoplasms (Breast Cancer)
10/2022 - 09/2006
12Pre-Eclampsia (Preeclampsia)
10/2014 - 01/2002
6Infections
09/2021 - 04/2015
4Carcinogenesis
01/2019 - 02/2010
4Uterine Cervical Neoplasms (Cancer of the Cervix)
08/2015 - 10/2004
3Triple Negative Breast Neoplasms
11/2021 - 01/2019
3Rupture
12/2020 - 12/2010
3Flushing
12/2018 - 12/2010
3Body Weight (Weight, Body)
10/2017 - 02/2010
2Urinary Tract Infections (Urinary Tract Infection)
09/2021 - 01/2021
2Bacteriuria
09/2021 - 01/2021
2Prostatic Neoplasms (Prostate Cancer)
01/2021 - 01/2020
2Diabetes Mellitus
05/2017 - 11/2009
2Inflammation (Inflammations)
04/2015 - 03/2012
2Herpes Zoster
01/2011 - 04/2006
1Vitamin D Deficiency
09/2021
1Asthenozoospermia
11/2020
1Premature Birth (Birth, Premature)
01/2019
1Bone Resorption
11/2017
1Azoospermia
02/2012
1Hepatocellular Carcinoma (Hepatoma)
01/2012
1Lymphoma (Lymphomas)
08/2011

Drug/Important Bio-Agent (IBA)

24Calcitriol (Calcijex)FDA LinkGeneric
10/2022 - 03/2007
6Vitamin DFDA LinkGeneric
01/2021 - 03/2007
6Proteins (Proteins, Gene)FDA Link
11/2020 - 10/2004
6Potassium Channels (Potassium Channel)IBA
01/2019 - 04/2009
6Antineoplastic Agents (Antineoplastics)IBA
11/2016 - 02/2010
6Insulin-Like Growth Factor I (IGF-1)IBA
10/2014 - 01/2002
5CytokinesIBA
01/2021 - 07/2009
5Hormones (Hormone)IBA
01/2021 - 02/2010
425-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)IBA
09/2021 - 03/2007
4Tyrosine Kinase InhibitorsIBA
01/2020 - 04/2015
4Calcitriol Receptors (Calcitriol Receptor)IBA
04/2015 - 07/2010
3CathelicidinsIBA
09/2021 - 11/2016
3Estrogen Receptor Modulators (Antiestrogen)IBA
01/2021 - 04/2009
3EnzymesIBA
01/2021 - 09/2006
3Estrogen ReceptorsIBA
01/2021 - 03/2014
3Mifepristone (RU 486)FDA Link
12/2020 - 01/2009
3Progesterone Receptors (Progesterone Receptor)IBA
12/2020 - 01/2009
3Testosterone (Sustanon)FDA Link
01/2019 - 09/2006
3ProgesteroneFDA LinkGeneric
01/2019 - 01/2009
3AstemizoleIBA
01/2019 - 01/2012
3Estradiol (Delestrogen)FDA LinkGeneric
12/2010 - 09/2006
31,25-dihydroxyvitamin DIBA
03/2007 - 08/2002
2Pharmaceutical PreparationsIBA
11/2021 - 10/2014
2Lapatinib (GW572016)FDA Link
01/2020 - 01/2017
2Biological ProductsIBA
11/2019 - 11/2009
2Gefitinib (Iressa)FDA Link
01/2019 - 04/2015
2Levonorgestrel (Plan B)FDA LinkGeneric
12/2018 - 11/2017
2Progesterone CongenersIBA
11/2017 - 02/2012
2Vitamin D3 24-HydroxylaseIBA
10/2017 - 01/2012
2Interleukin-10 (Interleukin 10)IBA
04/2015 - 03/2012
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2014 - 08/2013
2Messenger RNA (mRNA)IBA
01/2012 - 10/2004
2Ether (Diethyl Ether)IBA
07/2010 - 02/2010
2Magnesium Sulfate (Sulfate, Magnesium)FDA LinkGeneric
03/2009 - 02/2005
2LeptinIBA
04/2008 - 01/2002
2CalciumIBA
03/2007 - 08/2002
2AndrogensIBA
09/2006 - 07/2004
1Phenobarbital (Luminal)FDA Link
10/2022
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
10/2022
1AZD4547IBA
10/2022
1cyclo(arginylglycyl)IBA
11/2021
14- amino- 5- fluoro- 3- (5- (4- methylpiperazin- 1- yl)- 1H- benzimidazol- 2- yl)quinolin- 2(1H)- oneIBA
11/2021
1AcidsIBA
11/2021
1Biomarkers (Surrogate Marker)IBA
01/2021
1LipopolysaccharidesIBA
01/2021
1Antimicrobial PeptidesIBA
01/2021
1Interleukin-6 (Interleukin 6)IBA
01/2020
1DNA (Deoxyribonucleic Acid)IBA
01/2020
1Indomethacin (Indometacin)FDA LinkGeneric
01/2020
1Caspase 3 (Caspase-3)IBA
01/2020
1ResveratrolIBA
11/2019
1IntegrinsIBA
11/2019
1CurcuminIBA
11/2019
1PhytochemicalsIBA
11/2019
1Type I Tumor Necrosis Factor ReceptorsIBA
01/2019
1Cyclic AMP (AMP, Cyclic)IBA
01/2018
1GestodeneIBA
11/2017
1Mixed Function Oxygenases (Monooxygenases)IBA
10/2017
1Ethanol (Ethyl Alcohol)IBA
10/2017
1Calcifediol (Calcidiol)FDA Link
10/2017
1Advanced Glycation End ProductsIBA
05/2017
1seocalcitolIBA
01/2017
1neratinibIBA
01/2017
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2017
1Peptides (Polypeptides)IBA
11/2016
1Cholecalciferol (Vitamin D3)FDA Link
08/2015
1MicroRNAs (MicroRNA)IBA
08/2015
1Thrombospondin 1IBA
10/2014
1CytochromesIBA
01/2012
1Cytochrome P-450 CYP3AIBA
01/2012
1PhytohemagglutininsIBA
08/2011
1EstroneFDA Link
12/2010
1GlycodelinIBA
12/2010
1Estrogen Receptor alphaIBA
08/2010

Therapy/Procedure

10Therapeutics
10/2022 - 04/2009
2Drug Therapy (Chemotherapy)
10/2022 - 11/2021
1Intraperitoneal Injections
10/2014